菜单
Fetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele.
用 Codex 或 Claude 帮你安装 复制这段 Prompt，粘贴到 Codex、Claude 或其他助手里，让它检查 Skill 页面并帮你完成安装。
基于 SOC 职业分类
Use this skill for genetics, genome source, variant, gene, phenotype, disease, screen, pharmacogenomics, and Genomi install/setup maintenance questions.
Build and inspect ClinVar exact-match evidence and candidate inventories. Use for clinical labels, VUS/conflict, carrier context, and drug-response rows.
Activate this skill for "/genomi decode", "decode my genome", "decode my DNA", "show me the dashboard", "the Genomi dashboard", "one-shot rundown", or any all-at-once request that asks Genomi to compose every capability's findings into a single artifact. This is the whole-genome dashboard kicker — it sweeps every relevant Genomi capability in one shot, not a per-target lookup. Composes evidence from every relevant Genomi capability into a single self-contained Genomi Dashboard.html and returns localhost serve metadata. Active genome required.
Answer drug-response, medication, PharmGKB-style, PGxDB, ATC, DrugBank, gene-drug, and variant-drug questions using public PGx evidence plus local sample genotype support when an Active Genome Index is selected.
Plan rare disease, hereditary disease, cancer risk, carrier-relevance, and observed-condition source investigation from public targets or selected active genome evidence.
Answer specific rsID, allele, gene, region, genotype, and absence/callability questions using explicit session context or public evidence.
| name | genomi-gnomad |
| description | Fetch reusable public population allele frequencies from gnomAD for a specific variant. Use when the user asks about allele frequency, MAF, population stratification, gnomAD numbers, or rarity of a specific allele. |
| tools | ["genomi.invoke"] |
| mutating | true |
Fetch public gnomAD population allele frequencies for one variant. Results are cached locally in the evidence database so subsequent queries reuse them.
To call the tool below, invoke it through the MCP dispatcher:
genomi.invoke({
"tool": "gnomad.fetch_population_frequency",
"params": {
"chrom": "19",
"pos": 44908684,
"ref": "T",
"alt": "C",
"genome_build": "GRCh38"
}
})
The dispatcher validates the params against the underlying tool's input
schema and returns the underlying tool's response with an added
dispatched_tool field.
A scope-limited result from this capability is not a final user-facing answer when other Genomi capabilities can contribute orthogonal evidence to the same question. Returning "cannot answer" while applicable capabilities remain unexamined is a host-agent failure mode.
Fetch reusable gnomAD public population frequency for one allele and write it into evidence storage.
Use when: The agent needs gnomAD allele frequency, MAF, or population-stratified counts for a specific variant (rsID, chrom/pos/ref/alt, or VCF locus).
Why necessary: gnomAD is the canonical public population frequency source; cached results keep subsequent calls cheap.
Not for: Genome-wide rare-variant screening, ad-hoc curated annotations, anything not anchored to a specific variant.
Example prompts: What's the gnomAD frequency of rs429358? Is rs1042522 rare in East Asian populations?
Result semantics: Returns the gnomAD record with population-stratified counts and frequencies plus a populations block; writes to the local evidence database for reuse.