菜单
Universal genome data import supporting 23andMe v4/v5, AncestryDNA, MyHeritage, Nebula, and generic VCF. Also handles imputation prep and post-imputation import. Triggers on: /genome-import, "import my DNA data", "add raw file", "prepare for imputation", "import imputed data".
用 Codex 或 Claude 帮你安装 复制这段 Prompt，粘贴到 Codex、Claude 或其他助手里，让它检查 Skill 页面并帮你完成安装。
基于 SOC 职业分类
Goal-driven onboarding for new genome vault users. Triggers on: /genome-onboard, "set up my vault", "I just imported my data", "help me get started with my genome". Two modes: --quick (4 questions, fast vault bootstrap) or --full (22-question interview with validated psychological instruments, generates Profile Card + Action Plan).
Daily health tracking with genetic context: supplements, medications, symptoms, interventions, metrics. Use this skill whenever the user mentions taking supplements, logging symptoms, tracking health, reporting how they feel, or asks about their daily routine. Also triggers on: /genome-log, /log, "daily check-in", "track today", "I took my supplements", "feeling anxious", "my stomach hurts", "forgot my B12", "log symptoms", "how am I doing", "what did I take today". Even casual health mentions like "my nose is stuffed" or "had a rough night" should trigger this skill to offer logging.
Query Obsidian vault frontmatter with SQL-like syntax. Filter, sort, group, and aggregate notes by any frontmatter field. Replaces Dataview for CLI use. Triggers on: /genome-query, "query vault", "find notes", "list genes", "show protocols", "vault stats", "vault schema", "filter by".
Multi-agent validation pipeline for fact-checking claims, verifying evidence tiers, and ensuring prescriber document accuracy. Uses Codex CLI, NotebookLM, PubMed subagents, and Tavily search. Supports: audit (full vault), gene SYMBOL (single gene fact-check), protocol NAME (protocol/report fact-check). Triggers on: /genome-validate, "validate this note", "fact-check", "cross-check claims", "verify evidence", "audit this report", "fact-check gene X", "check protocol X".
Run analysis scripts: PRS, enrichment, vault audit, PubMed monitoring, consistency checks. Triggers on: /genome-analytics, "run PRS", "audit vault", "check PubMed", "run enrichment", "check consistency", "analyze pathway".
Create gene, system, or phenotype notes from SQLite genotype data and templates. Triggers on: /new-gene SYMBOL, /new-system NAME, "add gene X", "create system note", "create phenotype note for X".
| name | genome-import |
| description | Universal genome data import supporting 23andMe v4/v5, AncestryDNA, MyHeritage, Nebula, and generic VCF. Also handles imputation prep and post-imputation import. Triggers on: /genome-import, "import my DNA data", "add raw file", "prepare for imputation", "import imputed data". |
Import raw genome data from any supported DTC provider or VCF file.
$GENOME_VAULT_ROOT or config/default.yamldata/genome.dbdata/raw/ (user places their file here)config/provider_formats.yamlpython3 scripts/genome_init.py --detect-only <file>python3 scripts/genome_init.py <file> --profile <name>Triggered by: "prepare for imputation", "I want to impute"
python3 scripts/prepare_for_imputation.py
bcftools norm --check-ref ws --fasta-ref hg19.fa output.vcf -o normalized.vcf
Triggered by: "import imputed data", user provides VCF files
data/output/imputed/ or ask userpython3 scripts/genome_init.py <vcf> --min-r2 0.3Common issues and fixes:
bcftools norm --check-ref ws before uploadchr1, HRC expects bare 1| Provider | Format | Assembly | Detection |
|---|---|---|---|
| 23andMe v4/v5 | TSV (4 cols) | GRCh37 | "23andMe" in comments |
| AncestryDNA | TSV (5 cols) | GRCh37 | allele1/allele2 columns |
| MyHeritage | CSV (4 cols) | GRCh37 | "RSID,CHROMOSOME,POSITION,RESULT" |
| Nebula | VCF | from header | "source=Nebula" |
| Generic VCF | VCF | from header | "##fileformat=VCF" |