m4

Calculate APACHE IV (Acute Physiology and Chronic Health Evaluation IV) score for ICU mortality prediction. Use for severity assessment, hospital mortality prediction, ICU benchmarking, or case-mix adjustment. eICU has pre-computed scores; MIMIC-IV requires custom implementation with diagnosis mapping challenges.

Start a structured clinical research session. Use when users describe research goals, want to analyze cohorts, investigate hypotheses, or need a rigorous research plan. Interviews the user, then produces a research protocol.

Use the M4 Python API to query clinical datasets programmatically. Use when writing code to access clinical databases, executing SQL via Python, or performing multi-step data analysis.

Diagnose and repair common M4 environment, dataset, skill installation, backend, and vitrine setup problems. Use when M4 tools, datasets, skills, or visualization are missing or broken.

Calculate Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index for hospital admissions. Use for risk adjustment, mortality prediction, case-mix analysis, or comparing comorbidity burden across patient populations.

Identify first ICU stays and first hospital admissions for cohort selection. Use to exclude readmissions, create independent observations, or build adult patient cohorts.

Guide users through creating M4 skills with proper structure, provenance tracking, and tier assignment. Use when users want to create a new M4 skill, document a clinical concept, or contribute a skill to the M4 skills library.

Use the vitrine display API for M4 research visualization, review cards, forms, study tracking, approvals, exports, and recovery of displayed results.

Calculate SOFA (Sequential Organ Failure Assessment) score for ICU patients. Use for sepsis severity assessment, organ dysfunction quantification, mortality prediction, or Sepsis-3 criteria evaluation.

Calculate Charlson Comorbidity Index (CCI) and Elixhauser Comorbidity Index for hospital admissions. Use for risk adjustment, mortality prediction, case-mix analysis, or comparing comorbidity burden across patient populations.

Calculate MELD (Model for End-Stage Liver Disease) score for ICU patients. Use for liver disease severity assessment, transplant prioritization, or hepatology research.

Extract and calculate Glasgow Coma Scale (GCS) for ICU patients. Use for neurological assessment, consciousness monitoring, or trauma severity scoring.

Calculate OASIS (Oxford Acute Severity of Illness Score) for ICU patients. Use for mortality prediction with fewer variables than APACHE/SAPS, or when lab data is limited.

Calculate OASIS (Oxford Acute Severity of Illness Score) for ICU patients. Use for mortality prediction with fewer variables than APACHE/SAPS, or when lab data is limited.

Calculate SAPS-II (Simplified Acute Physiology Score II) for ICU patients. Use for mortality prediction, severity assessment, or international ICU benchmarking.

Calculate SIRS (Systemic Inflammatory Response Syndrome) criteria for ICU patients. Use for historical sepsis definitions, inflammatory response assessment, or research comparing SIRS vs Sepsis-3.

Classify ventilation status into InvasiveVent, NonInvasiveVent, HFNC, SupplementalOxygen, Tracheostomy, or None from charting data. Use for ventilation duration analysis, respiratory support characterization, or as a component of severity scores (SOFA respiratory, OASIS).

Calculate rolling urine output rates (mL/kg/hr) over 6/12/24-hour windows for ICU patients. Use for KDIGO AKI staging (urine output criterion) or SOFA renal component.

Calculate rolling urine output rates (mL/kg/hr) over 6/12/24-hour windows for ICU patients. Use for KDIGO AKI staging (urine output criterion) or SOFA renal component.

Calculate norepinephrine-equivalent dose for vasopressor comparison. Use for hemodynamic support quantification, shock severity assessment, or vasopressor weaning studies.

Calculate norepinephrine-equivalent dose for vasopressor comparison. Use for hemodynamic support quantification, shock severity assessment, or vasopressor weaning studies.

Calculate APACHE III (Acute Physiology Score III) for ICU patients. Use for mortality prediction, severity stratification, case-mix adjustment, or risk-adjusted outcome comparisons.

Estimate baseline serum creatinine for AKI assessment. Use for KDIGO staging, AKI research, or renal function baseline establishment.

Extract and calculate Glasgow Coma Scale (GCS) for ICU patients. Use for neurological assessment, consciousness monitoring, or trauma severity scoring.

Calculate KDIGO AKI (Acute Kidney Injury) staging for ICU patients using creatinine and urine output criteria. Use for nephrology research, AKI outcome studies, or renal function monitoring.

Calculate KDIGO AKI (Acute Kidney Injury) staging for ICU patients using creatinine and urine output criteria. Use for nephrology research, AKI outcome studies, or renal function monitoring.

Calculate MELD (Model for End-Stage Liver Disease) score for ICU patients. Use for liver disease severity assessment, transplant prioritization, or hepatology research.

Identify Sepsis-3 patients using the consensus definition (SOFA >= 2 + suspected infection). Use for sepsis cohort studies, outcome research, or quality metrics.

Identify suspected infection events using antibiotic administration plus culture timing. Use as a component of Sepsis-3 definition or for infection research.

Calculate SOFA (Sequential Organ Failure Assessment) score for ICU patients. Use for sepsis severity assessment, organ dysfunction quantification, mortality prediction, or Sepsis-3 criteria evaluation.

Classify ventilation status into InvasiveVent, NonInvasiveVent, HFNC, SupplementalOxygen, Tracheostomy, or None from charting data. Use for ventilation duration analysis, respiratory support characterization, or as a component of severity scores (SOFA respiratory, OASIS).

Calculate OASIS (Oxford Acute Severity of Illness Score) for ICU patients. Use for mortality prediction with fewer variables than APACHE/SAPS, or when lab data is limited.

Extract and calculate Glasgow Coma Scale (GCS) for ICU patients. Use for neurological assessment, consciousness monitoring, or trauma severity scoring.

Calculate MELD (Model for End-Stage Liver Disease) score for ICU patients. Use for liver disease severity assessment, transplant prioritization, or hepatology research.

Classify ventilation status into InvasiveVent, NonInvasiveVent, HFNC, SupplementalOxygen, Tracheostomy, or None from charting data. Use for ventilation duration analysis, respiratory support characterization, or as a component of severity scores (SOFA respiratory, OASIS).

Calculate LODS (Logistic Organ Dysfunction Score) for ICU patients. Use for organ dysfunction assessment across 6 systems with weighted scoring.

Guided workflow for statistical and ML analysis of clinical data. Use when planning or executing research analyses on MIMIC, eICU, or similar EHR data. Ensures methodological rigor through structured consultation, assumption checking, and stepwise execution with audit trails.

Calculate SAPS-II (Simplified Acute Physiology Score II) for ICU patients. Use for mortality prediction, severity assessment, or international ICU benchmarking.

Identify Sepsis-3 patients using the consensus definition (SOFA >= 2 + suspected infection). Use for sepsis cohort studies, outcome research, or quality metrics.

Calculate SIRS (Systemic Inflammatory Response Syndrome) criteria for ICU patients. Use for historical sepsis definitions, inflammatory response assessment, or research comparing SIRS vs Sepsis-3.