ksb-d08-k0028

name	KSB-D08-K0028
description	Causal Inference Applications: Propensity score matching for signal validation, instrumental variable analysis, causal graph constr...
version	1.0.0
domain	D08
domain_name	Signal Detection & Management
type	Knowledge
proficiency_level	L5
bloom_level	evaluate
triggers	["explain causal inference applications","what is causal inference applications","evaluate causal inference applications"]
epa_mapping	EPA-04, EPA-05
cpa_mapping	CPA-02
regulatory_refs	FDA-GUID-006, EMA-GVP-005, EMA-GVP-010, CIOMS-VIII

KSB-D08-K0028: Causal Inference Applications

Overview

Domain: D08 - Signal Detection & Management Type: Knowledge Proficiency Level: L5 (Expert - Can supervise others) Bloom Level: Evaluate

Description

Propensity score matching for signal validation, instrumental variable analysis, causal graph construction, counterfactual reasoning

Context

• Major Section: Multi-Source Data Integration and Intelligence Synthesis
• Section: Advanced Analytical Methodologies and Innovation

EPA Mapping

• EPA-04:3009-3010
• EPA-05:3011-3012

CPA Pathway

• CPA-02

Regulatory References

• FDA-GUID-006
• EMA-GVP-005
• EMA-GVP-010
• CIOMS-VIII

Instructions

When this skill is activated, Claude should:

1. Demonstrate L5 proficiency in causal inference applications
2. Apply evaluate level cognitive skills to evaluate the topic
3. Reference relevant regulatory guidance (FDA-GUID-006, EMA-GVP-005, EMA-GVP-010, CIOMS-VIII)
4. Connect to related EPAs: EPA-04, EPA-05

Key Competencies

• Propensity score matching for signal validation, instrumental variable analysis, causal graph construction, counterfactual reasoning

Assessment Criteria

• Can evaluate core concepts independently
• Demonstrates understanding of regulatory context
• Applies knowledge appropriately to PV scenarios

Related Skills

• Other D08 skills in Advanced Analytical Methodologies and Innovation
• Cross-domain integrations per DAG architecture

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Generated from PV KSB Framework v1.0 | 2025-12-31