chart-review-acts

name

chart-review-acts

description

ACTS Alzheimer's/dementia phenotyping — extract from a patient's clinical notes: impaired cognition (impaired_cognition), the documented APOE genotype (apoe_genotype → ε2/ε3/ε4 allele flags computed), postmenopausal status + last menstrual period, documented cognitive / depression / neuropsychiatric scale scores (MoCA, MMSE, CDR, Hachinski, Mattis DRS, TICS, GDS, Cornell, NPI, Global Deterioration stage), education years, and smoking status. Evidence-cited. Triggers on: impaired cognition, MCI, dementia, APOE, ε2/ε3/ε4, postmenopause, LMP, MoCA, MMSE, CDR, Hachinski, NPI, GDS, smoking, ACTS.

Procedure

This is a notes-only phenotype task. You extract each leaf field that the chart documents, with an evidence citation. Some fields are computed and you must NOT set them: the APOE allele flags (apoe2/apoe3/apoe4) derive from apoe_genotype, and the severity bands (moca_severity, mmse_severity, cdr_severity) derive from their scores.

Leaf fields you extract (only when the note documents them):

• Cognition / status: impaired_cognition (1/0).
• APOE: apoe_genotype — full genotype (e2/e2,e2/e3,e2/e4,e3/e3, e3/e4,e4/e4), single-allele carrier (e2_carrier/e3_carrier/e4_carrier), or none. (apoe2/apoe3/apoe4 auto-derive.)
• Reproductive: postmenopause (1/0), lmp_date (free-text date/expr).
• Cognitive scale SCORES (numeric, raw integer as documented): moca_score (0–30), mmse_score (0–30), mattis_drs (0–144), tics_score (0–41), hachinski_score (0–18).
• Staging (enum): cdr_global (0/0.5/1/2/3), gds_stage (1–7, the Reisberg Global Deterioration Scale).
• Depression / neuropsych SCORES (numeric): gds_depression_score (Geriatric Depression Scale, 0–30), cornell_csdd (0–38), npi_total (0–144).
• Demographics: education_years (integer), smoking_status (current/former/never/unknown).
• Smoking detail (only for current/former smokers): pack_year (number), pack_per_day (number, may be decimal), smoking_duration (years), quit_time (free-text: year / age-at-quit / relative time — former smokers only). Record only numbers/expressions the note states; do not compute them.
• Allergy / vaccine (structured ENTITY LISTS — a JSON array of records, one per substance/vaccine; [] when none):
  • allergen — a JSON list of allergen records, one per substance the patient reacts to. Each record: { "Allergen": <verbatim substance>, "Supporting_Evidence": <verbatim snippet>, + optional Category / Type / Reaction / Severity / Clinical_Status / Verification_Status }. [] for NKDA / no allergen.
  • vaccine_name — a JSON list of vaccine records, one per administered/ received/completed vaccine. Each record: { "Vaccine_Name": <verbatim>, "Category": <Live / Non-Live / BCG / Active Amyloid or Tau Immunization / Not a vaccine / Ambiguous>, "Administration_Date": <date or omit>, "Supporting_Evidence": <verbatim snippet> }. Category is now an attribute folded into each vaccine entity, assigned via references/CDC_Vaccine_Reference_Table.md + Active_Amyloid_Tau_Immunization_Reference_Table.md. [] when no vaccine.

1. list_notes; use search_notes for high-signal terms (MCI, dementia, Alzheimer, APOE, ε4, MoCA, MMSE, CDR, Hachinski, NPI, GDS, Cornell, DRS, TICS, postmenopausal, LMP, smoking, pack, education). read_note/read_notes to read candidates in full.

2. list_criteria + read_criteria([...]) for each field's schema + guidance. Follow each criterion's rules exactly.

3. For each DOCUMENTED field, commit one answer via set_field_assessment(field_id, answer, confidence, evidence, rationale). The answer must match the field's type: a listed value for enum fields, the raw numeric score (a number) for numeric fields, or the free-text value (LMP). Leave a field unanswered if the note does not document it — do not guess a score.

   Evidence rules — cite the SMALLEST affirmative span (e.g. "MoCA 21/30", "APOE ε3/ε4", "Postmenopausal"). Use find_quote_offsets for exact offsets. Never cite a negated sentence to support a positive.

Decision rules

• Patient-only, affirmative: extract only what is documented for THIS patient. Exclude family history, plans/orders ("memory workup planned", "APOE testing ordered"), and negations.
• Numeric scores: record the raw documented number only (e.g. "MoCA 21/30" → 21), and cite the note span containing that number. Do NOT infer a score from a severity word, and do NOT compute the severity bands — those derive automatically. If the note documents NO number for a scale, set its answer to null (leave it unanswered) — never write 0 as a placeholder. 0 is a real, severe score (a MoCA/MMSE of 0 = profound impairment) and would both corrupt the scale and cascade a bogus "severe" band into its derived severity. (The platform rejects an agent's numeric answer whose value is not in the cited quote, so an ungrounded 0 will be refused — answer null instead.)
• APOE = one extraction: read the documented genotype into apoe_genotype (full, *_carrier, or none); never set the allele flags by hand. "homozygous ε4" = e4/e4; "ε4 carrier" = e4_carrier. Do not infer APOE from an AD diagnosis, cognitive status, risk, or family history.
• Cognition: subjective concern alone, transient delirium, or evaluation-only → 0; confirmed MCI/dementia, clinician-corroborated decline, or impaired objective testing → 1.
• LMP: extract the date/time EXPRESSION only; an age of menopause is NOT an LMP. Smoking: "denies tobacco" → never, "quit 2015" → former, "1 ppd" → current.
• Allergen (JSON entity list, [] when none): one record per substance, Allergen = the SUBSTANCE only (not the reaction — that goes in the optional Reaction attribute); include resolved/inactive (set Clinical_Status); exclude NKDA (→ []), family history, refuted/entered-in-error, suspected, panel orders, bare reaction words. Vaccine (JSON entity list, [] when none): one record per vaccine, only administered/received/completed (exclude planned/declined/contraindicated/discussed). Category is now an attribute inside each vaccine entity — assign from the reference tables (brand→abbreviation→disease, brand wins; for disease-only mixed-category; passive mAbs = ) — do not guess from memory.

4. Commit every documented leaf field via set_field_assessment; leave undocumented fields unanswered. Do NOT set the computed fields (apoe2, apoe3, apoe4, moca_severity, mmse_severity, cdr_severity). Do NOT call set_review_status. Emit a one-line summary and stop.