القائمة
Open Targets gene-disease association lookup via the official MCP connector. One GraphQL round trip per gene. Emits Tier C informational evidence.
التثبيت باستخدام Codex أو Claude انسخ هذا Prompt والصقه في Codex أو Claude أو مساعد آخر ليراجع صفحة Skill ويثبّتها لك.
استنادا إلى تصنيف SOC المهني
Standing watcher. Reruns the trial, literature (PubMed + bioRxiv), and ClinVar-relookup specialists against the FIXED profile and diffs against the stored baseline. Empty diff -> one calm "no significant changes" timeline entry.
PubMed + bioRxiv search for recent literature on the patient's genes and diagnosis. bioRxiv preprints are first-class (earliest signal). Emits Tier C; the LLM only summarizes genuine free text, it never asserts facts.
ClinicalTrials.gov v2 search for trials relevant to the patient's diagnosis and genes. Eligibility is surfaced as "may be eligible — confirm with your care team", never confirmed. Emits Tier C.
Uncertainty-ranked gap report (spec §8b). For an unresolved (Tier B) variant, names that the analysis can't resolve it and attributes the gap to a missing input — a documented family history — that would let the analysis weight it. Never a test order.
Uncertainty-ranked gap report (spec §8b). Names a pharmacogenomic module the analysis could NOT complete and attributes the gap to a specific missing input (a genotype). Never tells the patient to get a test — it is a report on the tool's blind spots for the care team.
Deterministic CPIC pharmacogenomics lookup over the patient's current medications. Pure code, no LLM. Emits Tier A/B for CPIC Level A/B gene-drug pairs; flags a missing genotype instead of ever directing a dose change.
| name | target-open-targets |
| kind | oneshot |
| domain | target |
| description | Open Targets gene-disease association lookup via the official MCP connector. One GraphQL round trip per gene. Emits Tier C informational evidence. |
For each gene on the profile, query Open Targets (official MCP connector, one
GraphQL round trip) for gene-disease associations relevant to the existing
diagnosis. Emits Tier C informational EvidenceRecords: association score,
the disease, and a resolvable Open Targets URL as source_url.
Framing rules (spec §2): report associations as literature/association facts ("associated with ... in Open Targets"), never as anything the patient "has".
STATUS: stub. The MCP call is not wired yet; run_specialist returns [] so the
coordinator runs cleanly end-to-end. Wire the Open Targets MCP connector, map each
association to an EvidenceRecord(domain="target", tier="C", ...), and verify the
source_url is well-formed before emitting.
