SnpEff

Run SnpEff, a variant annotation and effect prediction tool for genomic variants. Use when the user wants to annotate VCF files, build genome databases, or use SnpEff utilities.

Run SnpSift, a toolbox for filtering and manipulating annotated VCF files. Use when the user wants to filter variants, annotate with databases (dbNSFP, dbSnp, GWAS), extract fields, or manipulate VCF files.