| name | pharmacology |
| description | Pharmacotherapy expertise including drug interactions, dosing optimization, medication safety, and therapeutic decision-making |
| metadata | {"version":"1.0.0","author":"HALO Core","tags":["medical","pharmacology","drug-interactions","medication-safety"]} |
Pharmacology Skill
Use this skill when evaluating medications, assessing drug interactions, or making pharmacotherapy recommendations.
When to Use
- Reviewing prescription medications
- Assessing drug-drug or drug-disease interactions
- Dosing recommendations (renal/hepatic impairment)
- Therapeutic drug monitoring
- Medication reconciliation
- Alternative therapy suggestions
Medication Review Framework
1. Indication Assessment
- Is each medication appropriately indicated?
- Is there evidence-based support for use?
- Are there more effective alternatives?
2. Dosing Evaluation
- Is the dose appropriate for the patient?
- Renal function adjustment (creatinine clearance)
- Hepatic function consideration
- Weight-based dosing where applicable
3. Interaction Analysis
Check for:
- Contraindicated: Never use together
- Major: Significant clinical impact
- Moderate: May require monitoring
- Minor: Minimal clinical significance
Categories:
- Pharmacodynamic (additive/synergistic/antagonistic)
- Pharmacokinetic (absorption, distribution, metabolism, excretion)
4. Adverse Effects
- Common and serious adverse effects
- Monitoring parameters
- Preventive measures
5. Patient Factors
Consider:
- Age (geriatric/pediatric)
- Renal/hepatic function
- Pregnancy/lactation
- allergies
- Comorbidities
Output Structure
Medication Review:
[Medication 1]
- Indication: [appropriate?]
- Dose: [appropriate?] - adjustments needed?
- Interactions: [list with severity]
- Monitoring: [recommended parameters]
Recommendations:
1. [Continue/Modify/Discontinue] - rationale
2. [Add alternative] - rationale
3. [Monitoring plan]
Common Interaction Categories
Cardiovascular
- QT prolongation combinations
- Anticoagulant interactions
- Beta-blocker + CYP interactions
CNS
- Sedative combinations
- Serotonergic drugs (SSRI, SNRI, triptans)
- Anticholinergic burden
Metabolic
- Statin interactions (CYP3A4)
- Sulfonylurea interactions
- Metformin contraindications
Anti-infective
- Antibiotic interactions
- Antifungal/viral interactions
- QT prolongation
Dosing Resources
Reference standard dosing guides:
- FDA labeling
- Lexicomp/Micromedex
- UpToDate
- Nejm grug information
Best Practices
- Always verify current guidelines
- Consider patient-specific factors
- Provide alternatives when issues identified
- Include monitoring recommendations
- Add appropriate disclaimers
