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SkillsMP hat 420 Skills aus eightmm/codex-science gesammelt. Öffne einen Skill, um Quelle und Details zu prüfen.
eightmm/codex-scienceEs werden 40 von 420 gesammelten Skills angezeigt.
Validate docking, pose-prediction, rescoring, and virtual-screening workflows with leakage-aware controls and prespecified metrics. Use before interpreting AutoDock Vina, GNINA, DiffDock, or related docking outputs.
Quellsprache: Englisch
Formulate, solve, simulate, and verify electrostatics, magnetostatics, circuits, induction, electromagnetic waves, and boundary-value problems using Maxwell's equations, potentials, constitutive relations, and conservation laws.
Quellsprache: Englisch
Extract reproducible ESM-2 protein embeddings, residue representations, likelihoods, or zero-shot mutation scores. Use when a frozen protein language model is needed as a feature extractor or baseline.
Quellsprache: Englisch
Run released Biohub ESMC protein language models for representations, masked likelihoods, sequence scoring, mutation analysis, or sparse-autoencoder features. Use as the current ESMC alternative to ESM-2 when model scale, revision, and inference boundaries…
Quellsprache: Englisch
Run the legacy public ESMFold v1 single-sequence structure model reproducibly for proteins or simple multimers. Use for the 2022 ESM-2-based model; use the separate ESMFold2 skill for Biohub's 2026 diffusion/all-atom model.
Quellsprache: Englisch
Run Biohub ESMFold2 locally from the released Hugging Face weights or through the approved Biohub Platform. Use for all-atom prediction of proteins, complexes, DNA, modifications, and ligands with optional MSA input and diffusion sampling; distinct from the…
Quellsprache: Englisch
Run pinned Evo 2 DNA sequence scoring, embeddings, variant scoring, or controlled generation. Use for long-context genomic foundation-model analyses when compatible local GPU hardware and explicit genome/strand provenance are available.
Quellsprache: Englisch
Formulate and verify geometry and topology arguments. Use for metric and topological spaces, continuity, compactness, connectedness, manifolds, curves and surfaces, homotopy, covering spaces, Euler characteristic, and geometric invariants.
Quellsprache: Englisch
Run reproducible local GNINA docking or CNN rescoring on protein-ligand systems. Use when GPU-assisted pose generation, refinement, or CNN reranking is wanted; keep CNN pose score, predicted affinity, and experimental affinity as distinct quantities.
Quellsprache: Englisch
Prepare and run staged, checkpointed molecular dynamics with a pinned GROMACS build. Use when GROMACS workflows, HPC execution, established .mdp protocols, or interoperability with GROMACS topology/trajectory formats is required.
Quellsprache: Englisch
Build an evidence-traceable indication dossier for a disease, target, mechanism, drug, biomarker, or therapeutic hypothesis. Use for landscape assessment, target-indication rationale, clinical pipeline review, translational gaps, and evidence-backed go/no-go…
Quellsprache: Englisch
Formulate and solve inverse problems with stable regularization and calibrated uncertainty. Use for parameter or field recovery, deconvolution, tomography, system identification, data assimilation, Bayesian inversion, and learned inverse models.
Quellsprache: Englisch
Solve exact and numerical linear algebra problems with explicit field, dimensions, bases, rank structure, conditioning, and residual checks. Use for linear systems, vector spaces, linear maps, eigenproblems, least squares, SVD, quadratic forms, and matrix…
Quellsprache: Englisch
Identify and quantify support for analytes from mass spectrometry with explicit acquisition context, calibration, false-discovery control, and isomer-aware evidence. Use for GC-MS, LC-MS, MS/MS, accurate mass, isotope patterns, adducts, fragments, library…
Quellsprache: Englisch
Analyze OpenMM, GROMACS, and other molecular dynamics trajectories with MDAnalysis using topology-aware selections, periodic-boundary handling, prespecified observables, convergence checks, and uncertainty estimates.
Quellsprache: Englisch
Drive a concrete scientific modeling problem from supplied inputs through model selection, falsifiable plan, one-time approval, environment setup, smoke test, full execution, downstream analysis, provenance, and review. Use when the user provides sequences,…
Quellsprache: Englisch
Prepare receptors and small molecules for docking or simulation with explicit stereochemistry, protonation, tautomer, charge, conformer, cofactor, water, and pocket provenance. Use before AutoDock Vina, GNINA, DiffDock, OpenMM, GROMACS, or any protein-ligand…
Quellsprache: Englisch
Process, assign, and verify molecular NMR evidence. Use for 1D or 2D solution NMR, FID processing, chemical shifts, multiplicities, couplings, integrations, COSY, HSQC, HMBC, NOE or ROE evidence, mixture assessment, and molecular structure or stereochemical…
Quellsprache: Englisch
Formulate and verify nuclear and particle physics calculations. Use for reactions, decays, relativistic kinematics, conservation laws, cross sections, lifetimes, quantum numbers, detector yields, backgrounds, and statistical significance.
Quellsprache: Englisch
Classify, solve, approximate, and verify ordinary and partial differential equations with explicit domains, initial or boundary data, well-posedness, residuals, and convergence checks. Use for IVPs, BVPs, dynamical systems, eigenvalue problems, Fourier…
Quellsprache: Englisch
Parameterize drug-like small molecules for molecular simulation with pinned OpenFF Toolkit/force fields and explicit charge, stereochemistry, and coverage checks. Use before OpenMM or GROMACS when ligands or nonstandard organic molecules need parameters.
Quellsprache: Englisch
Run pinned OpenFold3 preview inference for proteins, nucleic acids, noncanonical residues, and small-molecule complexes. Use when an open AlphaFold3-style workflow is wanted and preview-status limitations are acceptable.
Quellsprache: Englisch
Build, equilibrate, run, checkpoint, and analyze reproducible molecular dynamics with OpenMM. Use for proteins, nucleic acids, solvated complexes, or parameterized protein-ligand systems when local CPU/GPU simulation is requested.
Quellsprache: Englisch
Model and verify optical and wave phenomena. Use for ray optics, wave propagation, polarization, interference, diffraction, coherence, resonators, dispersion, scattering, imaging, and electromagnetic boundary problems.
Quellsprache: Englisch
Formulate, solve, and verify finite-dimensional optimization and calculus-of-variations problems. Use for convex programs, constrained extrema, KKT systems, duality, optimal control, Euler-Lagrange equations, and numerical optimization.
Quellsprache: Englisch
Profile noncovalent protein-ligand interactions with a pinned PLIP release and compare interaction fingerprints across experimental structures, docking poses, or trajectory representatives. Use after structure preparation or pose generation.
Quellsprache: Englisch
Formulate, solve, simulate, and verify probability and stochastic-process problems. Use for conditional probability, random variables, limit theorems, Markov chains, Poisson processes, martingales, stochastic simulation, and uncertainty in random systems.
Quellsprache: Englisch
Design or score protein sequences for fixed backbones with ProteinMPNN, LigandMPNN, or SolubleMPNN. Use for backbone-conditioned design, ligand-context design, soluble-protein design, residue constraints, or side-chain packing.
Quellsprache: Englisch
Run pinned Protenix structure prediction for protein, nucleic-acid, ligand, antibody-antigen, template, MSA, or constrained complexes. Use Protenix-v2 or another explicitly selected released model with a recorded training-data cutoff and inference budget.
Quellsprache: Englisch
Formulate, solve, simulate, and verify nonrelativistic quantum mechanics problems using states, operators, boundary conditions, symmetries, stationary and time-dependent evolution, approximation methods, measurement, and open-system dynamics.
Quellsprache: Englisch
Formulate and verify special- and general-relativity problems. Use for Lorentz transformations, four-vectors, relativistic kinematics, metrics, geodesics, curvature, gravitational fields, horizons, and stress-energy dynamics.
Quellsprache: Englisch
Run pinned RFdiffusion for unconditional generation, motif scaffolding, binder backbones, symmetric assemblies, partial diffusion, or macrocyclic peptide design. Use when structural conditioning and a downstream sequence/refolding validation funnel are…
Quellsprache: Englisch
Run RoseTTAFold All-Atom for proteins, nucleic acids, small molecules, metals, covalent modifications, and higher-order assemblies. Use when its Hydra input model and confidence metrics fit the problem and licensed dependencies are available.
Quellsprache: Englisch
Run pinned scGPT checkpoints for single-cell embeddings, cell-type annotation, reference mapping, perturbation modeling, or fine-tuning. Use when a pretrained single-cell transformer is requested and donor/batch/feature provenance can be preserved.
Quellsprache: Englisch
Build and evaluate reproducible scvi-tools workflows for single-cell RNA, protein, chromatin, spatial, or multimodal data using scVI, scANVI, totalVI, MultiVI, PeakVI, DestVI, or related models.
Quellsprache: Englisch
Run Apple's released SimpleFold flow-matching protein structure models with PyTorch or MLX. Use for single-protein folding, conformer ensembles, or Apple-silicon inference when model-size and model-license constraints are acceptable.
Quellsprache: Englisch
Analyze experimental spectra with traceable preprocessing, calibration, peak or band inference, uncertainty, and alternative-model checks. Use for UV-Vis, fluorescence, IR, Raman, absorbance, emission, reflectance, and related one-dimensional spectral…
Quellsprache: Englisch
Compute and verify tensor-calculus and differential-geometry results. Use for coordinate transformations, metrics, differential forms, covariant derivatives, connections, geodesics, curvature, Lie derivatives, and coordinate-independent geometric identities.
Quellsprache: Englisch
Solve and verify equilibrium thermodynamics and statistical mechanics problems using explicit systems, sign conventions, equations of state, thermodynamic potentials, ensembles, partition functions, fluctuations, and phase-equilibrium conditions.
Quellsprache: Englisch
Analyze and verify X-ray diffraction and scattering data. Use for powder XRD, phase identification, indexing, lattice parameters, Rietveld refinement, crystallite size or strain, texture, amorphous content, SAXS, WAXS, pair distributions, and comparison with…
Quellsprache: Englisch