variant-clinvar-lookup

name	variant-clinvar-lookup
kind	oneshot
domain	variant
description	Deterministic ClinVar classification lookup for the patient's variants. Pure code, no LLM. Emits Tier A for Pathogenic/Likely-Pathogenic at >=2-star review, Tier B for VUS.

variant-clinvar-lookup

A deterministic specialist (spec §7). It does not call an LLM. For each variant on the profile it looks up the ClinVar classification and review status and emits an EvidenceRecord with a fixed tier:

• Pathogenic / Likely-Pathogenic with >= 2-star review status -> Tier A
• Uncertain significance (VUS) -> Tier B (flagged preliminary; Evo2 may add signal)
• Benign / low-confidence -> not surfaced

The classification comes from app.clinvar.lookup, which reads the local ClinVar source (demo JSON now, tabix-indexed VCF in production). No fact here is asserted by a model, so none can be hallucinated.

Entrypoint: specialist.run_specialist(profile, ctx).