bigscape

name	bigscape
description	Cluster and compare biosynthetic gene clusters across genomes with BiG-SCAPE (similarity networks of antiSMASH regions). Use after batch antiSMASH for BGC family discovery. Upstream: https://github.com/medema-group/BiG-SCAPE.
license	MIT
category	analysis-tools
tags	["BGC","network","genome-mining","antiSMASH"]
upstream	https://github.com/medema-group/BiG-SCAPE
stage	mining

BiG-SCAPE

Upstream: medema-group/BiG-SCAPE

Citation

Navarro-Muñoz, J. C. et al. A computational framework to explore large-scale biosynthetic diversity. Nat. Chem. Biol. 16, 60–68 (2020). https://doi.org/10.1038/s41589-019-0400-9

Analytical thinking

BiG-SCAPE groups antiSMASH regions into BGC families via similarity networks. Requires consistent antiSMASH outputs. Family membership ≠ identical chemistry — use for prioritization and diversity plots.

How to run

# After antiSMASH on many MAGs into a common input layout (see BiG-SCAPE docs):
bigscape -i temp/antismash_collection -o temp/bigscape -c 16 \
  --mibig --include_gbk_dir

CLI flags evolve — verify with your BiG-SCAPE version help.

Related skills

antismash · microbial-mining · bakta · visualization