| name | report-generator |
| description | Generate professional drug discovery reports including target dossiers,
competitive briefs, and Go/No-Go decision summaries.
Use this skill when you need formatted reports for presentations,
decision meetings, or documentation. Supports multiple output formats.
Keywords: report, dossier, decision, go-no-go, brief, presentation
|
| category | Report Generation |
| tags | ["report","dossier","decision","go-no-go"] |
| version | 1.0.0 |
| author | Drug Discovery Team |
| dependencies | [] |
Report Generator Skill
Generate professional drug discovery intelligence reports.
Quick Start
/dossier EGFR --format pdf
/brief EGFR competitors --format ppt
/gng project-KRAS --full
/report --template competitor-brief
Generate a Go/No-Go report for HER2 inhibitor project
What's Included
| Report Type | Description | Use Case |
|---|
| Target Dossier | Comprehensive target analysis | Target validation meetings |
| Competitor Brief | Competitive intelligence summary | Portfolio reviews |
| Go/No-Go | Decision support with scoring | Investment decisions |
| Weekly Update | Weekly intelligence summary | Team updates |
| Project Overview | Full project analysis | Stakeholder reports |
Report Types
1. Target Dossier (/dossier)
Comprehensive target analysis for validation decisions.
Sections:
- Executive Summary (1 page)
- Target Overview
- Druggability Assessment
- Disease Associations
- Competitive Landscape
- Safety Assessment
- Opportunities & Risks
- Recommendations
Output: PDF (10-15 pages)
/dossier EGFR
/target-dossier KRAS G12C --format pdf
Generate dossier for BRAF V600E
2. Competitor Brief (/brief)
Competitive intelligence summary for portfolio reviews.
Sections:
- Market Overview
- Approved Products
- Pipeline Analysis
- Company Landscape
- Key Differentiators
- White Space
Output: PPT (8-12 slides)
/brief EGFR inhibitors
/competitor-brief GLP-1 agonists --format ppt
Create competitor brief for obesity market
3. Go/No-Go Analysis (/gng)
Decision support with multi-dimensional scoring.
Scoring Dimensions:
| Dimension | Weight | Assessment Criteria |
|---|
| Scientific Rationale | 25% | Target validation, disease linkage strength |
| Differentiation | 20% | Competitive advantage, novelty |
| Feasibility | 20% | Technical feasibility, developability |
| Commercial | 20% | Market size, unmet need, pricing |
| IP/Safety | 15% | Patentability, safety risk |
Score Interpretation:
- 80-100: Strong Go - Proceed with confidence
- 60-79: Go with conditions - Address specific concerns
- 40-59: Caution - Significant concerns, re-evaluate
- 0-39: No-Go - Do not proceed
Output: PDF with scorecard (5-8 pages)
/gng project-EGFR-4thgen
/go-no-go KRAS inhibitor --full
Generate Go/No-Go analysis for ADC program
4. Weekly Update (/weekly)
Weekly intelligence summary for team alignment.
Sections:
- Key Developments
- Literature Highlights
- Pipeline Updates
- Conference Abstracts
- Deals & News
Output: Email/Markdown (1-2 pages)
/weekly --targets EGFR,KRAS,HER2
/weekly-update --diseases NSCLC,CRC
Generate weekly report for oncology portfolio
5. Project Overview (/report --full)
Complete analysis combining all above sections.
Output: Full report (30-50 pages)
/report --full EGFR program
/generate full project report for KRAS G12C
Output Formats
| Format | Description | Use Case |
|---|
| Markdown | Default, fully formatted | Quick review, version control |
| PDF | Professional report | Meetings, archives |
| PPT | Slide deck | Presentations |
| One-pager | Single page summary | Executive updates |
Go/No-Go Scoring Example
# Go/No-Go Analysis: KRAS G12C Inhibitor Project
## Overall Score: 72/100 (Go with Conditions)
### Dimension Scores
| Dimension | Score | Weight | Weighted | Status |
|-----------|-------|--------|----------|--------|
| Scientific Rationale | 85/100 | 25% | 21.25 | ✅ Strong |
| Differentiation | 65/100 | 20% | 13.00 | ⚠️ Moderate |
| Feasibility | 75/100 | 20% | 15.00 | ✅ Good |
| Commercial | 80/100 | 20% | 16.00 | ✅ Strong |
| IP/Safety | 50/100 | 15% | 7.50 | ⚠️ Concern |
### Detailed Assessment
#### Scientific Rationale (85/100) ✅
**Strengths:**
- KRAS G12C validated in NSCLC, CRC
- Strong genetic association
- Clear mechanism of action
**Score:** 85/100
#### Differentiation (65/100) ⚠️
**Strengths:**
- First-in-class opportunity
- Novel covalent binding
**Concerns:**
- 4 competitors in Phase II/III
- Amgen and Mirati ahead
**Score:** 65/100
#### Feasibility (75/100) ✅
**Strengths:**
- Proven chemistry platform
- Clear PK/PD biomarkers
**Concerns:**
- Resistance mutations observed
- Combination complexity
**Score:** 75/100
#### Commercial (80/100) ✅
**Strengths:**
- Large NSCLC market
- Premium pricing potential
- Expansion to CRC, pancreatic
**Score:** 80/100
#### IP/Safety (50/100) ⚠️
**Concerns:**
- Patent landscape crowded
- Off-target toxicity risks
- Sotorasib safety signals
**Score:** 50/100
### Conditions to Proceed
1. **IP:** Conduct FTO analysis, explore novel binding pocket
2. **Safety:** Early toxicity profiling, off-target screening
3. **Differentiation:** Focus on combination strategies, CNS penetration
### Recommendation
**PROCEED with Conditions** - Strong scientific and commercial rationale,
but address IP position and safety profile before major investment.
Examples
Target Dossier
/dossier EGFR
Generate a target dossier for HER2
/target-dossier KRAS --focus safety
Competitor Brief
/brief EGFR TKIs
Create competitor brief for obesity drugs
/competitor-brief GLP-1 --format ppt --include-privates
Go/No-Go
/gng my-project-name
/go-no-go KRAS G12C --full
Generate decision report for ADC platform
Weekly Update
/weekly
/weekly-update --targets EGFR,KRAS --format email
Custom Report
/report --template custom --sections exec-sum,market,competition
/generate report using template project-overview
Running Scripts
python scripts/generate_dossier.py EGFR --format pdf --output reports/
python scripts/generate_brief.py "EGFR inhibitors" --format ppt
python scripts/generate_gng.py project-name --weights science=30,diff=15
python scripts/weekly_report.py --targets EGFR,KRAS,HER2 --format email
Requirements
For PDF/PPT generation:
pip install weasyprint python-pptx jinja2 pandas
Additional Resources
Best Practices
- Specify format: Always include output format
- Use templates: Reference existing templates for consistency
- Include context: Add project-specific considerations
- Review scores: Validate Go/No-Go assumptions
- Version control: Track report iterations
Report Templates
Templates are in templates/ directory:
templates/
├── target-dossier.md # Target validation report
├── competitor-brief.md # Competitive intelligence
├── go-no-go.md # Decision support
├── weekly-update.md # Weekly intelligence
└── project-overview.md # Full project analysis
Common Pitfalls
| Pitfall | Solution |
|---|
| Missing context | Include project background |
| Generic scores | Customize weights by project |
| Outdated data | Always refresh data before report |
| Too long | Use executive summary |
| Wrong format | Verify format before generation |
