report-generator

name	report-generator
description	Generate professional drug discovery reports including target dossiers, competitive briefs, and Go/No-Go decision summaries. Use this skill when you need formatted reports for presentations, decision meetings, or documentation. Supports multiple output formats. Keywords: report, dossier, decision, go-no-go, brief, presentation
category	Report Generation
tags	["report","dossier","decision","go-no-go"]
version	1.0.0
author	Drug Discovery Team
dependencies	[]

Report Generator Skill

Generate professional drug discovery intelligence reports.

Quick Start

/dossier EGFR --format pdf
/brief EGFR competitors --format ppt
/gng project-KRAS --full
/report --template competitor-brief
Generate a Go/No-Go report for HER2 inhibitor project

What's Included

Report Type	Description	Use Case
Target Dossier	Comprehensive target analysis	Target validation meetings
Competitor Brief	Competitive intelligence summary	Portfolio reviews
Go/No-Go	Decision support with scoring	Investment decisions
Weekly Update	Weekly intelligence summary	Team updates
Project Overview	Full project analysis	Stakeholder reports

Report Types

1. Target Dossier (/dossier)

Comprehensive target analysis for validation decisions.

Sections:

• Executive Summary (1 page)
• Target Overview
• Druggability Assessment
• Disease Associations
• Competitive Landscape
• Safety Assessment
• Opportunities & Risks
• Recommendations

Output: PDF (10-15 pages)

/dossier EGFR
/target-dossier KRAS G12C --format pdf
Generate dossier for BRAF V600E

2. Competitor Brief (/brief)

Competitive intelligence summary for portfolio reviews.

Sections:

• Market Overview
• Approved Products
• Pipeline Analysis
• Company Landscape
• Key Differentiators
• White Space

Output: PPT (8-12 slides)

/brief EGFR inhibitors
/competitor-brief GLP-1 agonists --format ppt
Create competitor brief for obesity market

3. Go/No-Go Analysis (/gng)

Decision support with multi-dimensional scoring.

Scoring Dimensions:

Dimension	Weight	Assessment Criteria
Scientific Rationale	25%	Target validation, disease linkage strength
Differentiation	20%	Competitive advantage, novelty
Feasibility	20%	Technical feasibility, developability
Commercial	20%	Market size, unmet need, pricing
IP/Safety	15%	Patentability, safety risk

Score Interpretation:

• 80-100: Strong Go - Proceed with confidence
• 60-79: Go with conditions - Address specific concerns
• 40-59: Caution - Significant concerns, re-evaluate
• 0-39: No-Go - Do not proceed

Output: PDF with scorecard (5-8 pages)

/gng project-EGFR-4thgen
/go-no-go KRAS inhibitor --full
Generate Go/No-Go analysis for ADC program

4. Weekly Update (/weekly)

Weekly intelligence summary for team alignment.

Sections:

• Key Developments
• Literature Highlights
• Pipeline Updates
• Conference Abstracts
• Deals & News

Output: Email/Markdown (1-2 pages)

/weekly --targets EGFR,KRAS,HER2
/weekly-update --diseases NSCLC,CRC
Generate weekly report for oncology portfolio

5. Project Overview (/report --full)

Complete analysis combining all above sections.

Output: Full report (30-50 pages)

/report --full EGFR program
/generate full project report for KRAS G12C

Output Formats

Format	Description	Use Case
Markdown	Default, fully formatted	Quick review, version control
PDF	Professional report	Meetings, archives
PPT	Slide deck	Presentations
One-pager	Single page summary	Executive updates

Go/No-Go Scoring Example

# Go/No-Go Analysis: KRAS G12C Inhibitor Project

## Overall Score: 72/100 (Go with Conditions)

### Dimension Scores

| Dimension | Score | Weight | Weighted | Status |
|-----------|-------|--------|----------|--------|
| Scientific Rationale | 85/100 | 25% | 21.25 | ✅ Strong |
| Differentiation | 65/100 | 20% | 13.00 | ⚠️ Moderate |
| Feasibility | 75/100 | 20% | 15.00 | ✅ Good |
| Commercial | 80/100 | 20% | 16.00 | ✅ Strong |
| IP/Safety | 50/100 | 15% | 7.50 | ⚠️ Concern |

### Detailed Assessment

#### Scientific Rationale (85/100) ✅
**Strengths:**
- KRAS G12C validated in NSCLC, CRC
- Strong genetic association
- Clear mechanism of action

**Score:** 85/100

#### Differentiation (65/100) ⚠️
**Strengths:**
- First-in-class opportunity
- Novel covalent binding

**Concerns:**
- 4 competitors in Phase II/III
- Amgen and Mirati ahead

**Score:** 65/100

#### Feasibility (75/100) ✅
**Strengths:**
- Proven chemistry platform
- Clear PK/PD biomarkers

**Concerns:**
- Resistance mutations observed
- Combination complexity

**Score:** 75/100

#### Commercial (80/100) ✅
**Strengths:**
- Large NSCLC market
- Premium pricing potential
- Expansion to CRC, pancreatic

**Score:** 80/100

#### IP/Safety (50/100) ⚠️
**Concerns:**
- Patent landscape crowded
- Off-target toxicity risks
- Sotorasib safety signals

**Score:** 50/100

### Conditions to Proceed

1. **IP:** Conduct FTO analysis, explore novel binding pocket
2. **Safety:** Early toxicity profiling, off-target screening
3. **Differentiation:** Focus on combination strategies, CNS penetration

### Recommendation
**PROCEED with Conditions** - Strong scientific and commercial rationale,
but address IP position and safety profile before major investment.

Examples

Target Dossier

/dossier EGFR
Generate a target dossier for HER2
/target-dossier KRAS --focus safety

Competitor Brief

/brief EGFR TKIs
Create competitor brief for obesity drugs
/competitor-brief GLP-1 --format ppt --include-privates

Go/No-Go

/gng my-project-name
/go-no-go KRAS G12C --full
Generate decision report for ADC platform

Weekly Update

/weekly
/weekly-update --targets EGFR,KRAS --format email

Custom Report

/report --template custom --sections exec-sum,market,competition
/generate report using template project-overview

Running Scripts

# Generate dossier
python scripts/generate_dossier.py EGFR --format pdf --output reports/

# Generate brief
python scripts/generate_brief.py "EGFR inhibitors" --format ppt

# Go/No-Go with custom weights
python scripts/generate_gng.py project-name --weights science=30,diff=15

# Weekly report
python scripts/weekly_report.py --targets EGFR,KRAS,HER2 --format email

Requirements

For PDF/PPT generation:

pip install weasyprint python-pptx jinja2 pandas

Additional Resources

• Template Reference
• Customization Guide
• Script Usage

Best Practices

1. Specify format: Always include output format
2. Use templates: Reference existing templates for consistency
3. Include context: Add project-specific considerations
4. Review scores: Validate Go/No-Go assumptions
5. Version control: Track report iterations

Report Templates

Templates are in templates/ directory:

templates/
├── target-dossier.md      # Target validation report
├── competitor-brief.md    # Competitive intelligence
├── go-no-go.md            # Decision support
├── weekly-update.md       # Weekly intelligence
└── project-overview.md    # Full project analysis

Common Pitfalls

Pitfall	Solution
Missing context	Include project background
Generic scores	Customize weights by project
Outdated data	Always refresh data before report
Too long	Use executive summary
Wrong format	Verify format before generation