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Deterministic CPIC pharmacogenomics lookup over the patient's current medications. Pure code, no LLM. Emits Tier A/B for CPIC Level A/B gene-drug pairs; flags a missing genotype instead of ever directing a dose change.
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SOC 職業分類に基づく
Open Targets gene-disease association lookup via the official MCP connector. One GraphQL round trip per gene. Emits Tier C informational evidence.
Standing watcher. Reruns the trial, literature (PubMed + bioRxiv), and ClinVar-relookup specialists against the FIXED profile and diffs against the stored baseline. Empty diff -> one calm "no significant changes" timeline entry.
PubMed + bioRxiv search for recent literature on the patient's genes and diagnosis. bioRxiv preprints are first-class (earliest signal). Emits Tier C; the LLM only summarizes genuine free text, it never asserts facts.
ClinicalTrials.gov v2 search for trials relevant to the patient's diagnosis and genes. Eligibility is surfaced as "may be eligible — confirm with your care team", never confirmed. Emits Tier C.
Uncertainty-ranked gap report (spec §8b). For an unresolved (Tier B) variant, names that the analysis can't resolve it and attributes the gap to a missing input — a documented family history — that would let the analysis weight it. Never a test order.
Uncertainty-ranked gap report (spec §8b). Names a pharmacogenomic module the analysis could NOT complete and attributes the gap to a specific missing input (a genotype). Never tells the patient to get a test — it is a report on the tool's blind spots for the care team.
| name | pgx-cpic-lookup |
| kind | oneshot |
| domain | pgx |
| description | Deterministic CPIC pharmacogenomics lookup over the patient's current medications. Pure code, no LLM. Emits Tier A/B for CPIC Level A/B gene-drug pairs; flags a missing genotype instead of ever directing a dose change. |
A deterministic specialist (spec §7). For each current medication it checks
whether a CPIC gene-drug pair exists and emits an EvidenceRecord:
The specific dosing guidance depends on the patient's metabolizer genotype. When no
genotype is on file (the normal demo case) the record states the pair exists and
flags the gap in confidence_note. It never emits a dose directive — the code
gate would block it, and next-data-pgx-coverage is what turns that gap into a
question for the care team.
Entrypoint: specialist.run_specialist(profile, ctx).
