来源信息
- 仓库
- ffsshhttiikk/opencode-agents-skills
- 最近来源活动
- 2026年2月28日 22:55
- 检测到的 SKILL.md 语言
- 英语
- 星标
- 2
- 分支
- 2
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SKILL.md
来源说明 · 只读预览- name
- structural
- description
- Structural biology fundamentals
- license
- MIT
- compatibility
- opencode
- metadata
- {"audience":"biologists, students, researchers","category":"biology"}
## What I do
- Explain molecular structure principles
- Describe protein structure organization
- Discuss structural analysis methods
- Analyze molecular interactions
- Connect structure to function
- Explain structural determination techniques
## When to use me
- When learning structural biology basics
- When explaining protein structure
- When studying molecular interactions
- When preparing educational content
## Key Concepts
### Biomolecular Structure
**Proteins**
- Amino acids linked by peptide bonds
- 20 standard amino acids
- Primary through quaternary structure
- Folding into 3D conformation
**Nucleic Acids**
- DNA: Double helix (B-form)
- RNA: Various structures (A, Z, hairpins)
- Nucleotides: Phosphate-sugar-base
### Molecular Interactions
```python
# Common interactions
interactions = {
'covalent': 'Strong, ~350 kJ/mol, shared electrons',
'ionic': 'Moderate, ~250 kJ/mol, charge-charge',
'hydrogen': 'Weak-moderate, ~20-40 kJ/mol, X-H---Y',
'hydrophobic': 'Weak, ~5 kJ/mol, entropy-driven',
'van_der_waals': 'Very weak, ~1 kJ/mol, induced dipoles'
}
# Bond types in biomolecules
bonds = {
'peptide': 'N-C, backbone',
'glycosidic': 'Sugar-sugar, sugar-base',
'phosphodiester': 'Nucleotide backbone'
}
```
### Techniques Overview
- X-ray crystallography
- NMR spectroscopy
- Cryo-EM
- Mass spectrometry
- Spectroscopy (UV, CD, fluorescence)
- Computational modeling
### Structure Databases
- PDB: Protein Data Bank
- NCBI Structure
- EMDB: Electron Microscopy DB
- AlphaFold DB
在 GitHub 查看